The Biggs collection is arranged in a series of 25 galleries, organized on a timeline, that balance painting, sculpture, architectural elements, furniture, silver and metals, ceramics, and textiles. The collection begins in 1700 and extends to the present, highlighting the important formal qualities the arts have shared since 18th century, emphasizing the evolution of Mid-Atlantic fashion in the fine and decorative arts, alongside national examples of American style.
The Museum displays a fine Delaware-made furniture and silver collection as well as a painting and sculpture collection that tracks the history of American representational art.